Table 2. Biochemical parameters measurements in normal (control) rats, in rats maintained 60 days on vitamin D free diet (VDD), in rats on normal diet treated for additional 30 days with tenofovir (TDF) and in rats on vitamin D free diet for 60 days, to which tenofovir was added on day 30 and continued throughout (VDD+TDF).
| C | VDD | TDF | VDD+TDF | |
| 25(OH)D | 15.4±1.0 | <1.5 (undetectable)c | 14.8±1.3 | <1.5 (undetectable)c,e |
| PTH | 120±11 | 1261±33c | 83±15 | 516±151b,e |
| Aldosterone | 116±15 | 243±46 | 316±57a | 479±83c,d |
| PP | 9.38±0.40 | 5.03±0.11c | 6.47±0.34c | 6.29±0.39c |
| PCa | 1.13±0.01 | 0.94±0.05c | 1.14±0.02 | 0.94±0.03c,f |
| PNa | 136±1 | 139±3 | 136±1 | 138±1 |
| PK | 3.9±0.3 | 4.3±0.2 | 3.7±0.2 | 4.1±0.2 |
| Cholesterol | 39±1 | 53±4a | 54±3a | 80±7c,f |
| Triglycerides | 17±4 | 34±5 | 59±9b | 74±13c |
| UPV | 14.9±1.1 | 17.0±0.9 | 18.7±0.8a | 21.5±0.7c,d |
| UCaV | 0.08±0.01 | 0.13±0.01 | 0.11±0.02 | 0.13±0.01 |
| UK/UNa | 3.27±0.17 | 3.39±0.16 | 3.07±0.18 | 4.46±0.49a,e |
| UProtV | 5.3±0.3 | 11.3±0.8c | 10.8±0.3c | 11.8±0.5c |
25(OH)D, 25 hydroxyvitamin D (ng/mL); PTH, parathormone (pg/mL); Aldosterone (pg/mL); PP, plasma phosphate concentration (mg/dL); PCa, plasma calcium concentration (mmol/L); PNa, plasma sodium concentration (mEq/L); PK, plasma potassium concentration (mEq/L); Cholesterol, total cholesterol (mg/dL); Triglycerides (mg/dL); UPV, urinary phosphorus excretion (mg/day); UCaV, urinary calcium excretion (mg/day); UK/UNa, urinary concentration of potassium and sodium ratio; UProtV, urinary protein excretion (mg/day). Values are means ± SEM. ap<0.05, bp<0.01, cp<0.001 vs. C; dp<0.05; ep<0.01, fp<0.001 vs. TDF.