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. 2014 Jul 22;5:345. doi: 10.3389/fimmu.2014.00345

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Copyright © 2014 Lange, Huang, Yu, Li, Liao, Zemlin, Su and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The average CDR3 length of identified V_H replacement products is significantly longer than that of non-V_H replacement products. The distribution of IgH genes with different CDR3 lengths is shown in the bar graph. The average CDR3 length of V_H replacement products (black bars) was compared to that of non-V_H replacement products (white bars). Statistical significance was determined by using an unpaired t-test. **p < 0.0001 is considered extremely statistically significant.