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. 2014 Jul 22;8:537. doi: 10.3389/fnhum.2014.00537

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Copyright © 2014 Hsieh, Stein and Howells.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NMDA receptor localization in the cortex. (A) Glutamatergic pyramidal neurons express NMDAreceptors preferentially in the post synaptic density (PSD) region, around the soma, and apical dendrites. Glutamate stimulation causes more focused calcium ion influx, and the cell has lower vulnerability to neurotoxicity (B) GABAergic interneurons express NMDA receptors more diffusely over the neuron, often at extrasynaptic locations. Glutamate stimulation causes widespread calcium ion influx, and the cell has greater vulnerability to neurotoxicity.