Simon 1965.

Methods	Allocation: random. Blinding: unclear. Duration: 30 days. Setting: hospital.
Participants	Diagnosis: DSM‐I schizophrenia (no further details), no prior treatment for schizophrenia, an average of 32.7 days treatment prior to evaluation for this study. N=80.           Age: average ˜ 31 years. Sex: all male.
Interventions	1. Chlorpromazine: dose minimum 200 mg/day, maximum 1200 mg/day, average 400mg/day.  n=20. 2. Hospital routine care (occupational and manual arts therapy, special services activities). N=20 3. Reserpine: dose minimum 2 mg/day, maximum 16 mg/da, average 6 mg/day. N=20. 4. Clinical judgement. N=20.
Outcomes	Leaving the study early. Not improved (Psychiatric improvement rating scale). Unable to use. Behaviour rating scale ‐ no usable data. Minnesota Multiphasic Personality Iinventory (MMPI) ‐ no usable data.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised ‐ no further details.
Allocation concealment (selection bias)	Unclear risk	No details.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No details.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No details.
Selective reporting (reporting bias)	Unclear risk	No details.
Other bias	Unclear risk	No details.