Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Aug;20(8):1195–1209. doi: 10.1261/rna.044644.114

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Mohammed et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

FIGURE 6. — High miRNA flux within testis-restricted cluster. (A) De novo miRNA birth is enriched within testes-restricted clusters compared with somatically expressed clusters. This enrichment is observed after normalizing to account for cluster size as measured by total number of conserved D. melanogaster miRNA orthologs. (B) Emergence of new miRNA within the mir-982-894 cluster via de novo hairpin emergence and gene duplication. A mir-982 subcluster containing three miRNAs (two mir-982 copies and mir-2582) duplicated in the D. simulans and D. sechellia lineage. Within D. sechellia, the duplicated copies remained similar; however, those of D. simulans experience gene loss and rapid sequence evolution. (C) De novo emergence of testis-restricted cluster in D. virilis. The 17 sense-strand miRNAs of this large cluster are testis-restricted (D) and interspersed among tRNA genes, while antisense members are predominantly expressed in other somatic tissues.