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. 2014 Jul 12;56(1):42. doi: 10.1186/s13028-014-0042-6

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Copyright © 2014 Stenfeldt et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Myocarditis in two pigs infected with FMDV A24 Cruzeiro (case 1; A-C) or FMDV O1 Campos (case 2; D-F). In both cases, FMDV VP1 capsid protein co-localizes with actin in cardiomyocytes. Myocardium from case 1 contains marked infiltrates of overlapping populations of CD44+ and CD163+ cells (B-C). Myocardium from case 2 has low numbers of CD172a + and CD163+ cells (E-F). A-C: FMDV A capsid (red), actin (blue), CD163 (turquoise), CD44 (green). D-F: FMDV O capsid (red), actin (blue), CD163 (turquoise), CD 172a (green). Multichannel immunofluorescence. Scale bars = 25 μm.