Table 3.

Interleukin (IL) genes that have been suggested to be associated with VKH disease

IL genes	Polymorphisms associated with VKH disease	Functional relevance	Race	References
IL-12B	rs3212227	C allele of rs3212227 of IL-12B is a risk factor of VKH disease. IL-12B is suggested to enhance Th1 production which is involved in the pathogenesis of VKH disease.	Chinese Han	Li et al. [[67]]
IL-17F	rs763780	TT genotype of IL-17F-rs763780 predisposes susceptibility to VKH disease, whereas the C allele of rs763780 may have protective effects against VKH disease.	Chinese Han	Shu et al. [[69]]
IL-23R	None discovered yet.	IL-23 levels are increased in the serum of VKH patients with active uveitis. IL-23 enhances production of IL-27 by CD4+ T cells.	Chinese Han	Jiang et al. [[73]]
IL-27	None discovered yet.	IL-27 is suggested to promote Th17 production which is involved in the pathogenesis of VKH disease.	Chinese Han	Yang et al. [[57]]