Table I.
Association of two SNPs of STAT4 with SSc of Han Chinese.
| Control | SSc | ||||
|---|---|---|---|---|---|
|
| |||||
| rs7574865 | N (%) | N (%) | p | OR (95%CI) | |
| genotype | GG | 265 (50) | 174 (38) | 4.1×10−4 | 0.63(0.49-0.82) |
| TT | 55 (10) | 62 (14) | 0.1 | 1.38(0.92-2.07) | |
| GT | 214 (40) | 217 (48) | 0.0135 | 1.37(1.06-1.78) | |
|
| |||||
| allele carrier |
G | 479 (90) | 391 (86) | 0.1 | 0.72(0.48-1.09) |
| T | 269 (50) | 279 (62) | 4.1×10−4 | 1.58(1.22-2.05) | |
|
| |||||
| total examined | 534 | 453 | |||
|
| |||||
| rs10168266 | |||||
|
| |||||
| genotype | CC | 251 (48) | 173 (39) | 0.0051 | 0.69(0.53-0.9) |
| TT | 58 (11) | 68 (15) | 0.051 | 1.45(0.98-2.15) | |
| CT | 218 (41) | 206 (46) | 0.14 | 1.21(0.93-1.5) | |
|
| |||||
| allele carrier |
C | 469 (89) | 379 (85) | 0.051 | 0.69(0.47-1.02) |
| T | 276(52) | 274 (61) | 0.0051 | 1.44(1.11-1.88) | |
|
| |||||
| total examined | 527 | 447 | |||
A p-value of multiple comparisons less than 0.0167 was considered significant after adjustment for 3 comparisons (rs7574865, rs10168266 and rs3821236, note: rs3821236 did not show any association). N: number; OR: odds ratio, CI: confidence interval