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PAEC proliferation in PVR is due, at least in part, to 15-KETE, the product of 15-PGDH. (A and B) Only 15-KETE, not 5,15-diHETE or 15-HPETE, increased cell viability and tube formation (n = 6). (C) 15-PGDH protein expression was down-regulated after transfecting the 15-PGDH siRNA sequence into PAECs (n = 4). (D) Cell proliferation was decreased after 15-PGDH silencing in normoxia (n = 4). Data shown are means ± SEM; *P < 0.05, significantly different from control.
