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. 2014 Jun 25;171(14):3463–3475. doi: 10.1111/bph.12694

Figure 1.

Figure 1

Right ventricular systolic pressure (RVSP) (A), mean arterial blood pressure (MABP) (B), right ventricle : left ventricle plus septum ratio [RV/(LV + S)] (C), total heart weights (D), plasma (cGMP) (E), and plasma (ANP) (F) in saline-treated (control) mice and animals 14 days after exposure to bleomycin (BLEO; 1 mg·kg−1) in the absence and presence of sildenafil (SILD; 30 mg·kg−1·day−1), ecadotril (ECAD; 60 mg·kg−1·day−1) or sildenafil plus ecadotril (doses as above). #P < 0.05 versus saline control; *P < 0.05 versus bleomycin; $P < 0.05 versus bleomycin in the presence of sildenafil or ecadotril monotherapy. n = 17–25 animals in each group for the haemodynamic measurements, n = 3–6 animals for the cGMP and ANP concentrations.