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. 2014 Jun 25;171(14):3463–3475. doi: 10.1111/bph.12694

Figure 4.

Figure 4

(A–F) Expression of mRNA encoding classical pro-fibrotic/pro-inflammatory mediators in the lungs of saline controls, bleomycin (BLEO; 1 mg·kg−1)-treated animals, and mice receiving bleomycin in the presence of sildenafil (SILD; 30 mg·kg·−1day−1), ecadotril (ECAD; 60 mg·kg−1·day−1) or sildenafil plus ecadotril (doses as above). #P < 0.05 versus saline control; *P < 0.05 versus bleomycin. n = 9 experiments for each group. (G) Expression of α smooth muscle actin (αSMA) by human fibroblasts under control conditions or stimulated with TGFβ (1 ng·mL−1) in the absence and presence of sildenafil (3 μM), atrial natriuretic peptide (ANP; 1 μM) or sildenafil plus ANP (at the same concentrations). #P < 0.05 versus saline control; *P < 0.05 versus TGFβ; $P < 0.05 versus TGFβ in the presence of sildenafil or ecadotril monotherapy. n = 9 experiments for each group.