. 2014 Jul 22;5:266. doi: 10.3389/fphys.2014.00266

Table 2.

ABC transporters involved the efflux of toxic compounds, fish species where they were identified and tissue distribution pattern in mammals and fish.

Protein	Mammals		Fish
	Tissue distribution	Localization in polarized cell	Specie	Common name	GenBank accession number	Tissue distribution
ABCB1	BBB, liver, intestine, kidney, placenta, stem cells	Apical	Barbus barbus	Barbel	DQ059069.1	Liver, intestine, kidney, brain, gonads^a^,^b^,^c^,^d^,^e^,^f^,^g^,^l^,^m
			Carassius auratus	Goldfish	DQ059072.1
			Chelon labrosus	Gray mullet	HM467814
			Chondrostoma nasus	Nase	AY948951.1
			Cyprinus carpus	Carp	AY999964.1
			Danio rerio	Zebrafish	XP_001922717
			Dicenthrarchus labrax	European seabass	GQ273979.1
			Fundulus heteroclitus	Killifish	AF099732.1
			Leuciscus cephalus	Chub	AY999966
			Mullus barbatus	Red mullet	AY850375.1
			Oncorhynchus mykiss	Rainbow trout	AY863423.3
			Oreochromis niloticus	Nile tilapia	GQ911571
			Plactichthys flesus	European flounder	AF175686.1
			Pleuronectes americanus	Winter flounder	AY053461.1
			Poeciliopsis lucida	Topminnow	DQ842514.2
			Scophtalmus maximus	Turbot	AJ291813
			Trematomus bernacchii	Rock cod	FJ938210.1
ABCB11	Liver	Apical	Chelon labrosus	Gray mullet	HM467813	liver, intestine^a^,^l^,^m
			Danio rerio	Zebrafish	XP_001923538
			Dicenthrarchus labrax	European seabass	GQ273980.1
			Fundulus heteroclitus	Killifish	AF135793.1
			Oncorhynchus mykiss	Rainbow trout	DQ865266.2
			Oreochomis niloticus	Nile tilapia	GQ911570
			Platichthys flesus	European flounder	AJ344042.1
ABCC1	Lung, testis, kidney, peripheral blood mononuclear cells, skeletal and cardiac muscle, placenta	Basolateral (apical in brain endothelial cells)	Barbus barbus	Barbel	FJ890350.1	testis, ovary, kidney, muscle, gills, heart, liver, intestine, brain, eye^a^,^h^,^l^,^m
			Chelon labrosus	Gray mulet	HM467810
			Danio rerio	Zebrafish	XM_002661202
			Dicenthrarchus labrax	European seabass	GQ273982.1
			Oncorhynchus mykiss	Rainbow trout	GQ166973.1
			Oreochromis niloticus	Nile tilapia	GQ911567
			Oryzias melastigma	Medaka	JN629038.1
			Plactichthys flesus	European flounder	AJ344044.1
			Poeciliopsis lucida	Topminnow	HM102361.1
			Trematomus bernacchii	Rock cod	FJ938212.1
ABCC2	BBB, liver, intestine, kidney, placenta, lung	Apical	Carassius auratus	Goldfish	FJ890349.1	liver, kidney, intestine, brain, muscle, gills^a^,ⁱ^,^j^,^k^,^l^,^m^,ⁿ
			Chelon labrosus	Gray mullet	HM467815
			Chondrostoma nasus	Nase	AY948950
			Cyprinus carpio	Carp	AY679169
			Danio rerio	Zebrafish	NM_200589.1
			Dicenthrarchus labrax	European seabass	GQ273983.1
			Leuciscus cephalus	Chub	FJ890348.1
			Mullus barbus	Barbel	AY275434.1
			Oncorhynchus mykiss	Rainbow trout	NM_001124655.1
			Oreochromis niloticus	Nile tilapia	GQ911569
			Plactichthys flesus	European flounder	AJ344045.1
			Poeciliopsis lucida	Topminnow	HM102360.1
			Trematomus bernacchii	Rock cod	FJ938211.1
			Raja erinácea	Little skate	AF486830
ABCC3	Adrenal gland, Intestine, Pancreas, Gallbladder, Placenta, Liver, Kidney, Prostate	Basolateral	Chelon labrosus	Gray mullet	HM467809	Liver ^a,^m
			Oncorhynchus mykiss	Rainbow trout	GQ888533
			Poeciliopsis lucida	Topminnow	DQ842515.1
ABCC4	Ovary, Testis, Kidney, Lung, Prostate	Apical, basolateral	Danio rerio	Zebrafish	NM_001007038.1	Liver^a
			Oncorhynchus mykiss	Rainbow trout	BX911853
ABCC5	Liver, Testis, Skeletal and Cardiac Muscle, Brain	Basolateral, apical	Danio rerio	Zebrafish	HQ161064	Liver^a
			Oncorhynchus mykiss	Rainbow trout	GU079635
ABCG2	BBB, placenta, liver, intestine, breast, stem cells	Apical	Chelon labrosus	Gray Mullet	HM467811.1	liver, kidney, gonads, intestine, gills^a^,^l^,^m
			Dicenthrarchus labrax	European seabass	GQ273981.1
			Oncorhynchus mykiss	Rainbow trout	EU163724.1
			Oreochromis niloticus	Nile tilapia	GQ911568
			Poeciliopsis lucida	Topminnow	HM102358.1
			Salmo salar	Atlantic salmon	NM_011736655.1

Loncar et al., 2010;

Kleinow et al., 2000;

Doi et al., 2001;

Bard et al., 2002a;

Bard et al., 2002b;

Klobučar et al., 2010;

Miller et al., 2002;

Long et al., 2011a;

ⁱ

Long et al., 2011b;

Miller et al., 2007;

Cai et al., 2003;

Costa et al., 2012b;

Diaz de Cerio et al., 2012;

ⁿ

Ferreira et al., 2014.