Table 3.
BRCA1/2 mutation, methylation and LOH analysis of ovarian cell lines.
| Cell line | BRCA1 | BRCA2 | |||||
|---|---|---|---|---|---|---|---|
| LOH | Gene variants | Mutation status | Methylated | LOH | Gene variants | Mutation status | |
| 59M | Yes | None | Wild‐type | No | No | 5,8,11,25 | Wild‐type |
| A1847 | Yes | 5,6,7,9,12,14,15,16 | Wild‐type | Yes | Yes | 5 | Wild‐type |
| A2780 | No | 9 | Wild‐type | No | No | 2,9,11,20,25 | Wild‐type |
| CAOV3 | ND | None | Wild‐type | No | ND | 1,10,23 | Wild‐type |
| DOV13 | No | 6,7,12,14,15,16 | Wild‐type | No | No | 11,25,26,33 | Wild‐type |
| EFO27 | No | 9 | Wild‐type | No | No | 1,10,14,21,23 | Wild‐type |
| ES2 | ND | 5,6,7,9,12,14,15,16 | Wild‐type | No | ND | 11,25,33 | Wild‐type |
| FUOV1 | Yes | None | Wild‐type | No | No | 11,25,33 | Wild‐type |
| HEY | No | 1,6,7,9,12,14,15,16 | Wild‐type | No | No | 1,10,23 | Wild‐type |
| HI0180 | ND | 6,7,9,14,15,16,17* | Wild‐type | No | ND | 1,10,23 | Wild‐type |
| HOC1 | No | 6,7,9,12,14,15,16 | Wild‐type | No | No | 1,5,10,23 | Wild‐type |
| HOC7 | No | 6,7,9,12,14,15,16 | Wild‐type | No | No | 1,5,10,23 | Wild‐type |
| HOC8 | ND | 6,7,9,12,14,15,16 | Wild‐type | No | ND | 10,23 | Wild‐type |
| IGROV1 | No | 4*,6,7,9,12,14,15,16 | Wild‐type | No | No | 1,10,13,23 | Wild‐type |
| IOSE29 | No | 6,7,9,12,14,15,16 | Wild‐type | No | No | 5,25 | Wild‐type |
| IOSE80 | No | 6,7,9,12,14,15,16 | Wild‐type | No | No | 1,23,31a | Wild‐type |
| ML46 | No | None | Wild‐type | No | No | None | Wild‐type |
| MPSCI | No | 6,8,9,14,16 | Wild‐type | No | No | 10,11,23,25,32 | Wild‐type |
| OAW28 | ND | 6,7,9,12,14,15,16 | Wild‐type | No | ND | 1,10,23 | Wild‐type |
| OAW42 | No | None | Wild‐type | No | No | 5,11,25 | Wild‐type |
| OC316 | No | 5,6,7,9,12,14,15,16 | Wild‐type | No | No | 5,18,19a,25 | Wild‐type |
| OCC1 | No | None | Wild‐type | No | No | 11,25 | Wild‐type |
| OVCA420 | No | 9 | Wild‐type | No | No | 10,11,22,23,25,33 | Wild‐type |
| OVCA432 | Yes | 9 | Wild‐type | No | No | 5,25,28,30a | Wild‐type |
| OVCA433 | Yes | None | Wild‐type | No | No | 5,25,28,30a | Wild‐type |
| OVCAR5 | No | 5,6,7,9,12,14,15,16 | Wild‐type | No | No | 5,11,25 | Wild‐type |
| OVCAR3 | Yes | None | Wild‐type | No | Yes | 1,10,23 | Wild‐type |
| OVCAR8 | Yes | 5,6,7,12,14,15,16, | Wild‐type | Yes | Yes | None | Wild‐type |
| OVCAR10 | ND | 9,10,11 | Wild‐type | No | ND | 3,9,11,20,24,25,27 | Wild‐type |
| PA1 | No | 13 | Wild‐type | No | No | 5,12,25 | Wild‐type |
| PEA1 | Yes | None | Wild‐type | No | Yes | 1,10,23 | Wild‐type |
| PEA2 | Yes | None | Wild‐type | No | Yes | 1,10,23 | Wild‐type |
| PEO1 | Yes | 6,7,9,12,14,15,16 | Wild‐type | No | Yes | 11,15c,16b,25 | Wild‐type |
| PEO4 | Yes | 6,7,9,12,14,15,16 | Wild‐type | No | Yes | 11,17c,25 | Wild‐type |
| PEO6 | Yes | 6,7,9,12,14,15,16 | Wild‐type | No | Yes | 11,17c,25 | Wild‐type |
| PEO14 | ND | 5,6,7,9,12,14,15,16 | Wild‐type | No | ND | 1,5,10,23,25 | Wild‐type |
| PEO23 | Yes | 5,6,7,9,12,14,15,16 | Wild‐type | No | No | 1,5,10,23,25 | Wild‐type |
| SKOV3 | No | None | Wild‐type | No | No | 1,10,21,23 | Wild‐type |
| SNU251 | ND | 18 | Mutant | No | ND | 5,25,29 | Wild‐type |
| SW626 | Yes | None | Wild‐type | No | Yes | 4,6,7,9 | Wild‐type |
| UPN251 | Yes | 2b,3b | Wild‐type | No | Yes | 5,25 | Wild‐type |
Numbered gene variants for BRCA1 and BRCA2 refer to Tables 2 and 4 respectively.
a
Heterozygous deleterious mutation.
b
Homozygous Deleterious mutation compensated for by another reversion mutation.
c
Reversion mutation.