Fig. 4.

Lung viral titers and cell counts in BAL fluid show similar cell numbers and cell population distributions following infection in GX^+/+ and GX^−/− mice. GX^−/− and GX^+/+ mice infected with A/Mexico/4108/2009 were investigated for lung cell numbers, populations and viral load. BAL fluid was harvested from infected GX^+/+ (open bars) and GX^−/− (filled bars) mice (C3H/HeN background mice) on day 0 and 6 and the cell numbers (Ai) and cell population distributions (Aii) were assessed by FACS. Viral load was determined on day 0, 3 and 6 pi of GX^+/+ (open bars) and GX^−/− (filled bars) mice by Real-Time RT-PCR vRNA quantification (B). All the mice used in these experiments were genotyped littermates and grouped and analyzed by their genotype. a, p<0.05 GX^+/+ vs. base, ANOVA followed by paired t-test, two tailed, assuming unequal variance. n≥7 per group.