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. 2014 Feb 25;454:78–92. doi: 10.1016/j.virol.2014.01.030

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© 2014 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 5 — Decreased eicosanoid levels in the BAL fluid 3 but not 6 days after infection with A/Mexico/4108/2009 in GX^−/− vs. GX^+/+ mice. The eicosanoid levels in the BAL fluid of GX^−/− and GX^+/+ mice (C3H/HeN background) were investigated at baseline and following infection with A/Mexico/4108/2009. GX^+/+ (open bars) and GX^−/− (filled bars) mice (C3H/HeN background mice) BAL fluid was harvested by instilling ice cold NaCl (1 ml) five times and pooled. Levels of PGD₂ MOX (A), LTB₄ (B), cysteinyl leukotrienes (C), PGE₂ (D), stable PGE metabolite (E), PGE₂ plus PGE metabolite (F) and Lipoxin A₄ (G) were assessed by ELISA. These results are the mean of 5 independent studies. All the mice used in these experiments were genotyped littermates and grouped and analyzed by their genotype. GX^+/+ (open bars) and GX^−/− (filled bars). Results are expressed in pg/mL. a, p<0.05 GX^+/+ or GX^−/− vs. base; b, p<0.05 GX^+/+ vs. GX^−/− at any time point, ANOVA followed by paired t-test, two tailed, assuming unequal variance. n≥7 per group.