Figure 4.
G-CSF-induced mobilization requires cooperation between β2- and β3-adrenergic receptors. β3-AR +/- and -/-, β2-AR +/+ and -/-, β2,β3-AR +/- and double K.O. littermates were injected with G-CSF (250 μg/kg/day, 8 divided doses every 12 h, i.p.). The number of circulating CFU-Cs was assessed 3 h after the last injection and normalized to the control group to account for strain-dependent differences in G-CSF-induced mobilization. A, n = 5; B, n = 5; C, n = 3-5. * p < 0.05, unpaired two-tail t test. Error bars indicate STD error.