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. Author manuscript; available in PMC: 2014 Jul 22.
Published in final edited form as: J Med Chem. 2013 Dec 12;56(24):10103–10117. doi: 10.1021/jm401543h

Figure 2.

Figure 2

Scaffold Ranking Library data for the 10 µg/mL dose (approximately 20 µM assuming an average molecular weight of 500 Da for each compound in a given mixture). Values are shown as percent inhibition of [3H]epibatidine binding to α4β2 (red) and α3β4 (blue) nAChR. The numbers along the x-axis represent the specific Scaffold Ranking Library sample, sc = solvent control (0.1%DMF), and the EPI (no.) are different concentrations of epibatidine (EPI(1) = 1 nM, (10) = 10 nM, (100) = 100 nM, (1000) = 1000 nM).