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. Author manuscript; available in PMC: 2014 Jul 22.
Published in final edited form as: J Med Chem. 2013 Dec 12;56(24):10103–10117. doi: 10.1021/jm401543h

Figure 6.

Figure 6

Compound 301 inhibits nicotine-induced α4β2 nAChR stimulation in a dose-dependent manner. Increasing concentrations of 301 induce a progressive decrease in maximal activity with a slight change in the EC50. EC50 and maximum stimulation were: 779 nM and 100%, 999 nM and 83%, 1809 nM and 38%, EC50 not measurable, maximum 0, for 0, 0.3, 1.0, and 3.0 µM 301, respectively.