Figure 9. Arterial oxygenation and dynamic compliance in surfactant-treated, ventilated rabbits with ARDS induced by in vivo lavage.

(A) Arterial partial pressure of oxygen (PaO₂ in torr) shown as a function of time for groups of at least 4 rabbits treated with synthetic lung surfactants containing synthetic lipids with 3.0% by weight SP-Cff, SP-Css ion-lock 1, SP-C33 ion-lock 1, SP-Cff ion-lock 1, and SP-C33 UCLA (positive control), or synthetic lipids alone (negative control). Synthetic lipids are DPPC:POPC:POPG (5:3:2, weight ratio). (B) Dynamic compliance (mL/kg/cm H₂O) shown as a function of time for groups of at least 4 rabbits treated with the same lung surfactant preparations as shown in (A). Data are shown as means ± SEM, for n = 4–7. Sequences for SP-C mimics are shown in Fig. 1.