Table 1.

Parameters in the model

Symbol	Definition	Unit	Value	Reference
${\mathit{r}}_{\mathit{g}}^{\left(0\right)}$	Rate constant for autophagosome formation (normal value)	s− 1	* 1.12 × 10− 5	[12], [13], [14]
k g	Constant for autophagosome formation (ATP dependency)	mM	* 4.01	[12], [14]
p g	Constant for autophagosome formation (ATP dependency)	mM	* 3.00	[12], [14]
a g	Constant for autophagosome formation (amino acids dependency)	mM	4.50
γ g	Constant for autophagosome formation (amino acids dependency)	(unitless)	* 1.22	[13]
ξ g	Constant for autophagosome formation (amino acids dependency)	mM− 1	* 7.49 × 10− 2	[13]
r l	Rate constant for autolysosome formation	s− 1	* 2.47 × 10− 5	[12], [14]
k l	Constant for autolysosome formation (ATP dependency)	mM	* 4.01	[12], [14]
p l	Constant for autolysosome formation (ATP dependency)	mM	* 3.00	[12], [14]
r h	Rate constant for intralysosomal hydrolysis	s− 1	* 1.39 × 10− 5	[12], [14]
δ h	Exponent for intralysosomal hydrolysis (ATP dependency)	(unitless)	* 7.24 × 10− 1	[12], [14]
k h	Constant for intralysosomal hydrolysis (ATP dependency)	mM	* 2.99	[12], [14]
r s	Rate constant for protein/organelle synthesis	mM ⋅ s− 1	* 1.48 × 10− 5	[34]
k s	Constant for protein/organelle synthesis (amino acids dependency)	mM	* 1.77 × 101	[34]
${\mathit{C}}_{\mathit{A}}^{\left(\mathit{m}\right)}$	ATP concentration corresponding to maximal protein/organelle synthesis rate	mM	3.00

Parameters with asterisks (*) are fixed, determined from biological experiments [12-14,34]. Those without asterisks are adjustable, depending on experimental setups.