Fig. 2.

Overexpression of the resistin gene in adipocytes leads to increased atherosclerotic progression. (a) Atherosclerotic plaque areas in aorta of female Ldlr^−/− mice, as imaged by Oil Red O for lipid deposition and MAC2 for macrophage accumulation, show increased plaque progression in Retn tg mice. (b) Quantified areas of Oil-Red-O-positive areas demonstrate significant increases in Retn tg mice (black bars) (areas relative to wild-type plaques on Ldlr^−/− background: white bars). (c) MAC2-positive area quantification demonstrated even greater differences between genotypes. *p<0.05 and **p<0.01 vs wild type