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. Author manuscript; available in PMC: 2015 Jun 3.
Published in final edited form as: Cell Metab. 2014 May 8;19(6):952–966. doi: 10.1016/j.cmet.2014.04.004

Figure 1. Disruption of ATP-dependent chromatin remodeling complex ISW2 extends yeast replicative lifespan.

Figure 1

(A) Replicative lifespan for wild-type (WT) and isw2Δ. Values in parenthesis (here and hereafter), are mean lifespan. (B) Mean replicative lifespan for strains deleted for chromatin remodeling ATPases. Values in brackets,are the number of cells tested. (C) Mean replicative lifespan for strains deleted for ISW2 complex subunits or via a catalytical mutant allele of ISW2. (D–E) Replicative lifespan for isw2Δ in combination with either sir2Δ or sir2Δ fob1Δ. (F) Quantitative real-time PCR analysis of rDNA copy number for young and old WT and isw2Δ cells. Values in parenthesis,are mean age. See also Figure S1 and Table S1.