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. Author manuscript; available in PMC: 2015 Jun 3.
Published in final edited form as: Cell Metab. 2014 May 8;19(6):952–966. doi: 10.1016/j.cmet.2014.04.004

Figure 2. Deletion of ISW2 extends lifespan through a novel mechanism exploited by calorie restriction.

Figure 2

(A–B) Replicative lifespan for isw2Δ under the moderate CR condition, YPD with 0.5% D-glucose (0.5%D), compared to the non-restricted (NR) condition, YPD with 2% D-glucose (2%D). (C–D) Replicative lifespan for isw2Δ under the severe CR condition, YPD with 0.05% D-glucose (0.05%D), compared to NR. (E–F) Replicative lifespan for isw2Δ in the tor1Δ (E) or gcn4Δ (F) background. (G) Gene expression analysis by RT-qPCR for selected 60S ribosome subunit genes. NR, SC with 2% glucose. CR, SC with 0.05% glucose. (H) Fold change in doubling time during exponential growth in SC media. * p values < 0.05 compared to WT NR. See also Table S1