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. Author manuscript; available in PMC: 2015 Jun 3.
Published in final edited form as: Cell Metab. 2014 May 8;19(6):952–966. doi: 10.1016/j.cmet.2014.04.004

Figure 4. ISW2 deletion partially mimics calorie restriction and potentiates stress response in old cells.

Figure 4

(A–B) GO clustering analysis for down-regulated (A) and up-regulated (B) genes in CR. GO categories with p <0.001 were included in enrichment score. (C) Venn diagram showing statistically significant overlap between up-regulated stress/abiotic stimulus response pathways in isw2Δ cells (61 genes) and in cells grown in CR conditions (81 genes). (D) Validation of gene expression by qPCR for overlapped genes. # p<0.05, ▼ p <0.01, compared to WT NR. (E) Gene expression for young and old, WT and isw2Δ cells. See also Figure S4 and Tables S3–S4.