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. Author manuscript; available in PMC: 2015 May 9.
Published in final edited form as: Ann Neurol. 2014 May 9;75(5):793–798. doi: 10.1002/ana.24164

Figure 2.

Figure 2

Immunopositive ubiquilin-2 inclusions in brain stem and hippocampus from two affected members of family 1T. Ubiquilin-2 positive intracytoplasmic aggregates (arrows) were identified in neurons in the inferior olivary nucleus along with sparse immunopositive neurites (A, individual II-3; B, individual III-3). Hippocampal aggregates of ubiquilin-2 were detected in the molecular layer (left side of section) of the fascia dentata (C, individual II-3; D, individual III-3). Ubiquilin-2 immunohistochemistry was performed with an ubiquilin-2 polyclonal antibody (Sigma Life Sciences) using diamobenzidine and a hematoxylin counterstain, x400 original magnification.