. Author manuscript; available in PMC: 2014 Jul 22.

Published in final edited form as: J Am Chem Soc. 2008 Jul 1;130(30):9836–9843. doi: 10.1021/ja801662y

Table 1.

Homopolymers

(a) Precursor polymer characterization by GPC^a
sample	monomer	M_{n. Target} g mol⁻¹	GPC M_n g mol⁻¹	M_w/M_n
Methyl_3k	methyl	3000	11 200	1.08
Ethyl_3k	ethyl	3000	9200	1.10
Propyl_3k	propyl	3000	9200	1.10
Butyl_3k	butyl	3000	11 500	1.08
Isopentyl_3k	isopentyl	3000	11 400	1.11
Hexyl_3k	hexyl	3000	11 000	1.08
Methyl_10k	methyl	10 000	49 000	1.05
Ethyl_10k	ethyl	10 000	11 300	1.10
Propyl_10k	propyl	10 000	28 200	1.07
Butyl_10k	butyl	10 000	26 700	1.07
Isopentyl_8k	isopentyl	8000	22 600	1.06
Isopentyl_10k	isopentyl	10 000	51 500	1.16
Hexyl_10k	hexyl	10 000	27 600	1.04

(b) Characterization of the antimicrobial homopolymers by biological assays^b
sample	MIC₉₀ μg mL⁻¹		HC₅₀ μg mL⁻¹	selectivty
sample	E. coli	S. aureus	HC₅₀ μg mL⁻¹	E. coli	S. aureus

Methyl_3k	>200	100	2000	<10	20
Ethyl_3k	50	50	1400	28	28
Propyl_3k	6.25	15	50	8.3	3.3
Butyl_3k	15	25	<50	<3.3	<2.0
Isopentyl_3k	12.5	50	<50	<4.0	<1.0
Hexyl_3k	>200	>200	<50	<0.3	<0.3
Methyl_10k	>200	>200	50	<10	<10
Ethyl_10k	>200	>200	1250	<6.3	<6.3
Propyl_10k	3.75	200	<50	13	<0.25
Butyl_10k	20	>200	<50	<2.5	<0.3
Isopentyl_8k	50	>200	<50	<0.3	<0.3
Isopentyl_10k	50	200	<50	<0.3	<0.3
Hexyl_10k	100	>200	n.d.	n.d.	n.d.

DMF, 0.01 mol L⁻¹ LiCl, PS standards.

Inhibitory activity towards bacterial growth of E. coli and S. aureus bacteria. (MIC₉₀ = minimal inhibitory concentration preventing 90% bacterial growth) and hemolytic activity towards red blood cells (HC₅₀ = concentration lysing 50% of blood cells).