Table 1. IGABA Modulation through α1β2γ2S GABAA Receptors by Indicated Compounds (100 μM)a.
| compd | modulation of IGABA (%) | n | compd | modulation of IGABA (%) | n |
|---|---|---|---|---|---|
| 1 | 0 ± 0 | 3 | 25 | 506 ± 74** | 3 |
| 2 | 10 ± 0 | 3 | 26 | 0 ± 0 | 3 |
| 3 | 5 ± 5 | 3 | 27 | 13 ± 13 | 3 |
| 4 | –15 ± 9 | 3 | 28 | 294 ± 66* | 3 |
| 5 | –2 ± 2 | 3 | 29 | 0 ± 0 | 3 |
| 6 | –7 ± 3 | 3 | 30 | 113 ± 17* | 3 |
| 7 | 8 ± 7 | 3 | 31 | –20 ± 20 | 3 |
| 8 | –8 ± 6 | 3 | 32 | –5 ± 5 | 3 |
| 9 | 0 ± 0 | 3 | 33 | 359 ± 50* | 3 |
| 10 | 1 ± 7 | 3 | 34 | 439 ± 31* | 3 |
| 11 | 51 ± 11 | 3 | 35 | 568 ± 54 | 3 |
| 12 | –6 ± 6 | 3 | 36 | 33 ± 9 | 3 |
| 13 | 33 ± 17 | 3 | 37 | 26 ± 14 | 3 |
| 14 | 0 ± 0 | 3 | 38 | 218 ± 43* | 3 |
| 15 | –1 ± 17 | 3 | 39 | 183 ± 20** | 3 |
| 16 | –6 ± 6 | 3 | 40 | 12 ± 8 | 3 |
| 17 | 79 ± 8* | 3 | 41 | 5 ± 5 | 3 |
| 18 | 66 ± 30 | 3 | 42 | 48 ± 12 | 3 |
| 20 | 61 ± 28 | 3 | 43 | 445 ± 74** | 3 |
| 21 | 258 ± 28 | 3 | 44 | 17 ± 17 | 3 |
| 22 | 986 ± 244* | 3 | 45 | –16 ± 14 | 3 |
| 23 | 1091 ± 257* | 3 |
a
All data are given as mean ± SEM. Asterisks indicate statistically significant differences from zero: *p < 0.05, **p < 0.01.