Table 2. IGABA Modulation through α1β2γ2S GABAA Receptors by Indicated Compounds (100 μM)a.
compd | modulation of IGABA (%) | n | compd | modulation of IGABA (%) | n |
---|---|---|---|---|---|
46 | 42 ± 1** | 3 | 62 | 13 ± 2 | 3 |
47 | 364 ± 55** | 3 | 63 | 12 ± 4 | 3 |
48 | 49 ± 7 | 3 | 64 | 4 ± 4 | 3 |
49 | 30 ± 15 | 3 | 65 | 105 ± 18 | 3 |
50 | 178 ± 32* | 3 | 66 | 67 ± 23 | 3 |
51 | 280 ± 52** | 3 | 67 | 18 ± 9 | 3 |
52 | 63 ± 12* | 3 | 68 | –1 ± 12 | 3 |
53 | 298 ± 31** | 3 | 69 | 74 ± 1* | 3 |
54 | 34 ± 8 | 3 | 70 | 32 ± 12 | 3 |
55 | 79 ± 24 | 3 | 71 | 32 ± 10 | 3 |
56 | 114 ± 11 | 3 | 72 | 334 ± 23** | 3 |
57 | 15 ± 15 | 3 | 73 | 514 ± 76** | 3 |
58 | –5 ± 12 | 3 | 74 | 60 ± 17 | 2 |
59 | 134 ± 39 | 3 | 75 | 58 ± 29* | 3 |
60 | 51 ± 21 | 3 | 76 | 122 ± 26* | 3 |
61 | 11 ± 2 | 3 | 77 | 138 ± 29* | 3 |
All data are given as mean ± SEM. Asterisks indicate significant differences from zero: *p < 0.05, **p < 0.01.