. 2014 Jun 6;57(13):5602–5619. doi: 10.1021/jm5002277

Table 5. Comparison of Potency and Efficiency of 23 for GABA_A Receptors of Different Subunit Compositions^a.

	α₁β₂γ_2S		α₁β₁γ_2S		α₁β₃γ_2S		α₂β₂γ_2S		α₃β₂γ_2S		α₄β₂γ_2S		α₅β₂γ_2S
	P	E	P	E	P	E	P	E	P	E	P	E	P	E
α₁β₂γ_2S				*				**				*
α₁β₁γ_2S					**		*				*			*
α₁β₃γ_2S													*
α₂β₂γ_2S												**	*	**
α₃β₂γ_2S
α₄β₂γ_2S													*
α₅β₂γ_2S

Potency (P), expressed as EC₅₀, and efficiency (E), expressed as I_GABA-max, are compared. Asterisks indicate statistical significance as follows: *p < 0.05, **p < 0.01.

Table 5. Comparison of Potency and Efficiency of 23 for GABAA Receptors of Different Subunit Compositionsa.

Table 5. Comparison of Potency and Efficiency of 23 for GABA_A Receptors of Different Subunit Compositions^a.