FIGURE 4.
PERK inhibition by GSK2606414 prevents clinical disease in prion-infected mice. a, mice were treated with GSK2606414 (blue) or vehicle (red) from 7 wpi. b–c, GSK2606414 restored global protein synthesis rates (b), prevented loss of novel object memory (c), and afforded marked neuroprotection in hippocampus (d). e, levels of total PrP and PrPSc (as shown by proteinase K digestion (PK)) were unaffected by treatment. f and g, clinical cure in treated mice with normal posture and movement of hind legs. All data in bar charts show mean ± S.E. Controls represent mice inoculated with normal brain homogenate (white bar) (n = 12 for each) (*, p < 0.01). Adapted from Ref. 32.