FIGURE 5.

Prosaposin and saposin A deficiency affects lipid content in the cornified layer. A, immunohistochemical analysis of filaggrin, active caspase-14, and mesotrypsin expression in wild-type and prosaposin-deficient mice. Merged figures of antibody staining images with nuclear staining images are also shown. Scale bars, 50 μm. B, Oil Red staining of skin of prosaposin-deficient and saposin A-deficient mice. Two skin examples each are shown for wild-type mice, prosaposin-deficient mice, and saposin A-deficient mice. Scale bars, 50 μm.