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. 2014 May 28;289(29):20054–20066. doi: 10.1074/jbc.M113.545111

FIGURE 3.

FIGURE 3.

Crystal structure of CoPP bound to the REV-ERBβ-LBD. A, overlay of CoPP- (blue) and heme- (orange; PDB code 3CQV) bound structures of the REV-ERBβ-LBD. B, overlay of the CoPP-bound (blue) and apo (yellow; PDB 2V0V) structures of the REV-ERBβ-LBD. C, cobalt-His-568 coordination distance (2.30 Å). The distance is 0.14 Å larger than the one observed for the iron-His-568 holo structure (2.16 Å) (PDB code 3CQV (11)). D, CoPP adopts a planar conformation in the LBD of REV-ERBβ-LBD different from the non-planar, puckered distortion observed for the heme group.