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. 2014 May 29;289(29):20307–20317. doi: 10.1074/jbc.M114.576249

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Activation of Akt and Erk signal transduction pathways by FL Reelin in dissociated cortical neurons. A, 5 DIV mouse cortical neurons were exposed to purified Reelin for 20 min and assayed by Western blotting. Both FL and CF Reelin induced Akt phosphorylation (Ser-473), but only FL Reelin induced Erk1/2 phosphorylation (Thr-202/Tyr-204). B, data were quantified from five independent experiments. The graphs show mean ± S.E. C and D, Time course of Akt and Erk1/2 phosphorylation by FL Reelin and quantification of the results from multiple experiments.