FIGURE 5.

Induction of p90RSK phosphorylation by FL Reelin in cortical neurons. A, representative confocal images of cortical neurons treated with control buffer or FL Reelin and processed for immunofluorescence using antibodies against phospho-p90RSK (green) and Map2 (red). B, Reelin significantly increased the percentage of double labeled neurons in the absence of inhibitors and in the presence of LY294002. U0126 pretreatment virtually abolished basal and Reelin-induced levels of phospho-p90RSK. n = 315–345 neurons from 14–15 visual fields per treatment. Scale bars, 50 μm. **, p < 0.01.