Table 1. Top 50 metabolic enzymes frequently over-expressed in human tumors.

Score denotes number of data sets (of 51 total) where each gene was significantly over-expressed at a false discovery rate (FDR) of 5%, as in Fig. 1. Rightmost columns indicate membership in pathways, as in Fig 1.

Score	Symbol	Description	Drug target	One-carbon	Nucleotides	Glycolysis	Hypoxia	Glycosylation
27	MTHFD2	methylene-THF dehydrogenase/cyclohydrolase (mitochondrial)		X
26	RRM2	ribonucleotide reductase M2	X		X
25	NME1	protein expressed in non-metastatic cells 1			X
23	GMPS	guanine monphosphate synthetase			X
23	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)		X
22	GGCT	gamma-glutamylcyclotransferase
22	UCK2	uridine-cytidine kinase 2			X
22	TYMS	thymidylate synthetase	X		X
22	TK1	thymidine kinase 1, soluble			X
21	PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3					X
21	ENO1	enolase 1 (alpha)				X
20	PYCR1	pyrroline-5-carboxylate reductase 1
20	DNMT1	DNA (cytosine-5-)-methyltransferase 1
19	FLAD1	flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
19	ALG3	asparagine-linked glycosylation 3 homolog (S. cerevisiae)						X
19	TSTA3	tissue specific transplantation antigen P35B						X
19	TPI1	triosephosphate isomerase 1				X
19	RPN2	ribophorin II						X
19	GPI	glucose-6-phosphate isomerase				X
18	PAICS	AIR carboxylase / SAICAR synthetase			X
18	DTYMK	deoxythymidylate kinase (thymidylate kinase)			X
18	ATIC	AICAR formyltransferase/IMP cyclohydrolase			X
17	MOGS	mannosyl-oligosaccharide glucosidase						X
17	PLOD1	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1					X
17	PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3
17	P4HA1	prolyl 4-hydroxylase, alpha polypeptide I					X
16	RPN1	ribophorin I						X
16	PKM2	pyruvate kinase, muscle				X
16	LDHA	lactate dehydrogenase A				X
16	HMBS	hydroxymethylbilane synthase
16	ALDOA	aldolase A, fructose-bisphosphate				X
15	SRM	spermidine synthase
15	GAPDH	glyceraldehyde-3-phosphate dehydrogenase				X
15	DHFR	dihydrofolate reductase	X	X
15	CTPS1	CTP synthase 1			X
15	CAD	carbamoyl-P synthetase 2/aspartate transcarbamylase/dihydroorotase			X
15	ACLY	ATP citrate lyase
14	ALG8	asparagine-linked glycosylation 8 (S. cerevisiae)						X
14	CHPF2	chondroitin polymerizing factor 2
14	UMPS	uridine monophosphate synthetase			X
14	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1
14	SLC7A1	solute carrier family 7 (y+ system), member 1
14	PMM2	phosphomannomutase 2						X
14	INPPL1	inositol polyphosphate phosphatase-like 1
14	APRT	adenine phosphoribosyltransferase			X
13	CHPF	chondroitin polymerizing factor
13	B3GAT3	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
13	EHMT2	euchromatic histone-lysine N-methyltransferase 2
13	SLC25A13	solute carrier family 25 (aspartate/glutamate carrier), member 13
13	DPM2	dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory						X