RAS mutation frequencies in study groups using three kinds of RAS mutation analyses (six codons, three codons, and single codon). aAnalysis of RAS mutation frequency between FTC group and FA or NH groups. FTC had significantly more RAS mutations than FA or NH groups in all three kinds of RAS mutation analyses (six codons, three codons, and single codon). bAnalysis of RAS mutation frequency between FTC M1 and FTC M0 groups. Only NRAS codon 61 mutation had a significant association with FTC M1 group. NH, nodular hyperplasia (n=12); FA, follicular adenoma (n=17); FTC, follicular thyroid carcinoma; FTC M0, FTC without a distant metastasis (n=28); FTC M1, FTC with distant metastases (n=28).