Figure 1.

The total use of mice and rats in behavioral testing. The number of publications were determined in PubMed using the search terms (mouse or mice) and (rat or rats) combined with (behavior or behaviour), where data prior to 1960 is excluded since the absence of abstracts in the older literature makes search results unreliable. A sharp rise in mouse behavioral testing can be seen in the last decade and is now slightly more prevalent than rat behavioral testing.