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. Author manuscript; available in PMC: 2014 Jul 22.
Published in final edited form as: Neuropharmacology. 2009 Feb 5;56(0):956–969. doi: 10.1016/j.neuropharm.2009.01.019

Figure 7. Comparison of the Effect of Zero and Sixty Minute Pretreatment Time for WC 44, WC 10, WC 26 and WC 21 on the Attenuation of AIM Scores.

Figure 7

The effect of novel D3 dopamine receptor selective compounds, WC 44, WC 10, WC 26 and WC 21 (10 mg/kg, i.p.) on total AIMs score is shown. Each of the test drugs were administered i.p. at either 60 minutes prior (solid bars) or simultaneously (zero minutes: hatched bars) to L-dopa/benserazide i.p. administration (8 mg/kg each). Values are the normalized mean scores ± S.E.M relative to vehicle controls (Control) normalized to 100. The number of independent experiments used to calculate the mean values is n > 8 for each condition except for WC 26 at 60 minutes (n = 5). There is a significance level between the vehicle control values and the 60 minute pretreatment is p ≤ 0.01 and the level of significance between the control values and the 0 minute pretreatment time is p ≤ 0.0001.