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. Author manuscript; available in PMC: 2015 Jul 31.
Published in final edited form as: Vaccine. 2014 Jun 18;32(35):4571–4577. doi: 10.1016/j.vaccine.2014.06.016

Figure 2.

Figure 2

Clinical signs and viral load in vaccinated ferrets challenged with wild-type H7N9 virus. Groups of 3 ferrets were vaccinated and challenged with 106 EID50 of virus 3 weeks later. Ferrets were monitored for weight (A) and temperature changes (B) daily up to 7 days post-infection. Data are presented as mean ± standard deviation of percentage of weight change over baseline (day 0, pre-infection). Viral shedding (C) was determined from nasal washes collected on days 3, 5, and 7 post-infection. Lung titers (D) were determined from three ferrets euthanized on day 5 post-infection. Viral titer data are presented as mean log10 TCID50/ml in nasal washes and mean log10 TCID50/g of tissue for lung titers. Statistical significance was determined using the ANOVA test with p<0.05 deemed significant compared with the PBS control group.