Figure 6.

Forest plot of essential hypertension associated with the MTHFR C677T gene polymorphism in the Asian population under the allelic model (T/C) stratified by different populations, including Chinese, Japanese and others (Indian and Turk). A significant association was revealed in the Asian population (OR, 1.37; 95% CI, 1.21–1.54), as well as the Chinese (OR, 1.39; 95% CI, 1.26–1.55) and the others (OR, 2.3; 95% CI, 1.56–3.40) subgroups. No significant association was found in the Japanese subgroup (OR, 0.97; 95% CI, 0.76–1.25). A significant heterogeneity was detected in the Asian group (I²=60.4%, P=0.000), but no longer existed in the Chinese (I²=31.4%, P=0.118), Japanese (I²=55.2%, P=0.107) and others (I²=17.9%, P=0.270) subgroup, through subgroup analysis. MTHFR, methylenetetrahydrofolate reductase; OR, odds ratio; CI, confidence interval.