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. 2014 May 29;20(8):745–755. doi: 10.1093/molehr/gau039

Figure 4.

Figure 4

p32 knockdown alters CTB proliferation. Term placental explants were transfected with a non-targeting siRNA sequence (NT; 50 nM) or two different siRNA sequences specific for p32 (siRNA 1, siRNA 2; 50 nM). After 72 h, proliferation and apoptosis were assessed by immunohistochemical analysis of (A–C) Ki67- and (D–F) M30-positive CTB. Arrowheads denote positive cells. (G) Percentage of Ki67-positive CTB. Median, n = 6; *P < 0.05, **P < 0.01, Kruskal–Wallis test. (H) Percentage of M30-positive CTB. Median, n = 4. (I) Necrosis was assessed by measuring LDH release into the culture medium. Median, n = 8.