FIGURE 3:

CO (A) and cardiac work (B) in the sham (n = 8) and AI (n = 7) animals able to withstand the 15-min ischemic bout (i.e. achieve aortic overflow post-ischemia) during the course of the ischemia–reperfusion perturbation at 5-, 10- and 15-min pre-ischemia as well as 20, 25 and 30 min post-ischemia. The CO and work were significantly impaired in the sham and AI animals post-ischemia relative to baseline. The AI animals also demonstrated impaired CO and work relative to the sham animals pre-ischemia and post-ischemia at 60 min. In contrast, no difference was observed in percent recovery (post-ischemic value/pre-ischemic value×100) of CO and work post-ischemia in the sham versus AI animals (C). Values are mean ± SEM (A and B) or mean with scatter plot distribution displayed (C); AI, 5/6 ablation–infarction animals, *P < 0.05 versus sham; ^#P < 0.05 versus 15-min pre-ischemia time-point.