Table 2.

Cardiac function during left atrial filling pressure manipulation

Left atrial filling pressure (cm H2O)	9.5	13.5	17.5	21.5
Aortic pressure (cm H2O)	80	80	80	80
Sham	280 ± 7	285 ± 8	287 ± 7	287 ± 7
AI	278 ± 16	285 ± 17	288 ± 18	286 ± 18
CO (mL × min−1 × g heart mass−1)
Sham	22 ± 3	31 ± 3**	33 ± 4**	34 ± 4**
AI	12 ± 3	16 ± 3*	16 ± 3*	17 ± 3*
Coronary flow (mL × min−1 × g heart mass−1)
Sham	10.2 ± 1.0	11.4 ± 0.9	12.0 ± 1.2	12.5 ± 1.5**
AI	6.0 ± 1.0	7.6 ± 1.2	7.7 ± 1.2	8.1 ± 1.6**
Systolic pressure (mmHg)
Sham	83 ± 2	90 ± 2**	89 ± 2**	89 ± 2**
AI	71 ± 2*	74 ± 2*	74 ± 2*	74 ± 2*
Diastolic pressure (mmHg)
Sham	41 ± 2	37 ± 2**	38 ± 1**	38 ± 2**
AI	45 ± 2	45 ± 2*	45 ± 1*	45 ± 1*
Cardiac work (SP × CO)
Sham	1843 ± 294	2810 ± 291**	2981 ± 409**	3026 ± 417**
AI	915 ± 258	1151 ± 241*	1192 ± 226*	1246 ± 238*
RPP (HR × SP)
Sham	23 181 ± 757	25 676 ± 841**	25 623 ± 844**	25 515 ± 944**
AI	19 856 ± 1398	20 902 ± 1154*	21 137 ± 1085*	21 112 ± 1092*
Maximum rate of ΔP (+dp/dt; mmHg × s−1)
Sham	1238 ± 95	1437 ± 79**	1407 ± 77**	1415 ± 78**
AI	830 ± 104*	898 ± 61*	919 ± 43*	912 ± 63*
Minimum rate of ΔP (−dp/dt; mmHg × s−1)
Sham	−894 ± 56	−1114 ± 47**	−1070 ± 50**	−1120 ± 72**
AI	−667 ± 73*	−669 ± 58*	−691 ± 46*	−710 ± 57*

Different measures of cardiac function in sham (n = 7) and 5/6 ablation–infarction (AI; n = 7) rats in response to altering atrial filling pressure.

Values are mean ± SEM; SP, systolic pressure; CO, cardiac output; RPP, rate pressure product; HR, heart rate; ΔP, change in pressure.

*P < 0.05 versus sham, **P < 0.05 versus 9.5-cm H₂O atrial filling pressure value.