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Glioma cell of origin and glioma stem cell (GSC) evolution. Normal cellular hierarchy comprises neural stem cells that progressively produce new stem cells and more restricted progenitor cells, finally yielding oligodendrocytes, astrocytes and neurons. Accumulation of genetic mutations in different cell types is sufficient to induce gliomas. These gliomas contain a population of GSCs with self-renewal capacity and ability to differentiate to all the lineages.
