Table 1.
Major discoveries associated to SOX2 protein in CNS tumors
| Sox member | Finding | Reference |
|---|---|---|
| SOX2-Glioblastoma | sustains stemness properties and tumorigenicity | [55] |
| Transcriptional regulation mediated by TGF-β | [56] | |
| Genetic and Epigenetic modifications | [53] | |
| Factor responsible for glioblastoma stem cells reprogramming | [57] | |
| SOX2-medulloblastoma | Sustains stemness properties but not involved in tumor survival | [78] |
| SOX2-oligodendroglioma | Required to maintain stemness properties and tumorigenicity | [71] |
| SOX4-Glioblastoma | Sustains stemness regulated by TGF-β and modulating SOX2 | [56] |