Table III.
Correlation between clinicopathological characteristics and tumor lymphocyte infiltration.
| A, Correlation between clinicopathological characteristics and number of interstitially infiltrating lymphocytes in the tumor | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Characteristics | iFoxP3 | P-value | iCD4 | P-value | iCD8 | P-value |
| Age, years | 0.9587 | 0.2258 | 0.2316 | |||
| >70 | 5.4 | 31.7 | 16.6 | |||
| ≤69 | 5.3 | 38.8 | 21.1 | |||
| Gender | 0.7112 | 0.0413 | 0.3380 | |||
| Male | 5.1 | 31.1 | 17.8 | |||
| Female | 5.9 | 43.6 | 21.5 | |||
| Tumor size, cm | 0.7903 | 0.7883 | 0.8905 | |||
| ≥3.0 | 5.7 | 34.5 | 19.4 | |||
| <3.0 | 5.1 | 36.0 | 18.8 | |||
| T factor | 0.6609 | 0.4704 | 0.1398 | |||
| T1a-b | 5.7 | 37.3 | 21.5 | |||
| T2–4 | 4.8 | 33.1 | 16.1 | |||
| Histology | 0.3714 | 0.3220 | 0.5105 | |||
| Adenocarcinoma | 6.0 | 37.5 | 19.9 | |||
| Other | 3.9 | 31.2 | 17.3 | |||
| N factor | 0.7582 | 0.3828 | 0.6965 | |||
| Negative | 5.5 | 34.0 | 118.7 | |||
| Positive | 4.7 | 40.1 | 20.4 | |||
| p-Stage | 0.6614 | 0.9614 | 0.2397 | |||
| I–II | 5.6 | 35.5 | 18.1 | |||
| III | 4.2 | 35.1 | 23.9 | |||
| Ly factor | 0.2930 | 0.6320 | 0.2930 | |||
| Negative | 6.1 | 34.4 | 20.3 | |||
| Positive | 3.6 | 37.6 | 16.2 | |||
| V factor | 0.5860 | 0.7802 | 0.8501 | |||
| Negative | 5.7 | 34.9 | 19.3 | |||
| Positive | 4.4 | 36.7 | 18.4 | |||
| Pl factor | 0.3873 | 0.6061 | 0.1595 | |||
| Negative | 5.9 | 34.5 | 20.5 | |||
| Positive | 3.8 | 38.0 | 14.7 | |||
| Recurrence | 0.9914 | 0.7614 | 0.8922 | |||
| Yes | 5.4 | 37.1 | 19.5 | |||
| No | 5.3 | 34.9 | 18.9 | |||
|
| ||||||
| B, Correlation between clinicopathological characteristics and number of centrally infiltrating lymphocytes in the tumor | ||||||
|
| ||||||
| Clinical characteristics | cFoxP3 | P-value | cCD4 | P-value | cCD8 | P-value |
|
| ||||||
| Age, years | 0.4626 | 0.7064 | 0.9857 | |||
| >70 | 2.0 | 8.8 | 7.0 | |||
| ≤ | 69 | 1.2 | 9.8 | |||
| Gender | 0.3777 | 0.3446 | 0.4761 | |||
| Male | 1.9 | 8.4 | 6.5 | |||
| Female | 0.9 | 11.1 | 8.0 | |||
| Tumor size, cm | 0.1659 | 0.0098 | 0.0036 | |||
| ≥3.0 | 0.6 | 5.1 | 3.7 | |||
| <3.0 | 2.2 | 12.2 | 9.3 | |||
| T factor | 0.0935 | 0.0199 | 0.0058 | |||
| T1a-b | 2.4 | 12.2 | 9.5 | |||
| T2–4 | 0.6 | 5.9 | 4.2 | |||
| Histology | 0.6971 | 0.0359 | 0.8868 | |||
| Adenocarcinoma | 1.7 | 11.3 | 7.1 | |||
| Other | 1.3 | 5.2 | 6.8 | |||
| N factor | 0.2457 | 0.2664 | 0.4223 | |||
| Negative | 1.9 | 10.1 | 7.5 | |||
| Positive | 0.4 | 6.5 | 5.5 | |||
| p-Stage | 0.4334 | 0.6448 | 0.7209 | |||
| I–II | 1.8 | 9.6 | 7.2 | |||
| III | 0.6 | 7.9 | 6.2 | |||
| Ly factor | 0.1850 | 0.6417 | 0.3064 | |||
| Negative | 2.1 | 10.9 | 7.9 | |||
| Positive | 0.5 | 5.2 | 4.7 | |||
| V factor | 0.1379 | 0.0607 | 0.1446 | |||
| Negative | 2.1 | 10.9 | 7.9 | |||
| Positive | 0.2 | 5.2 | 4.7 | |||
| Pl factor | 0.1024 | 0.0244 | 0.0066 | |||
| Negative | 1.8 | 11.1 | 8.6 | |||
| Positive | 0.1 | 4.2 | 2.7 | |||
| Recurrence | 0.4666 | 0.3956 | 0.1743 | |||
| Yes | 0.8 | 7.0 | 4.5 | |||
| No | 1.8 | 9.9 | 7.7 | |||
|
| ||||||
| C, Correlation between clinicopathological characteristics and the ratio of centrally/interstitially infiltrating lymphocytes | ||||||
|
| ||||||
| Characteristics | cFoxP3/iFoxP3, % | P-value | cCD4/iCD4, % | P-value | cCD8/iCD8, % | P-value |
|
| ||||||
| Age, years | 0.5000 | 0.9758 | 0.6371 | |||
| >70 | 39.4 | 37.2 | 66.4 | |||
| ≤69 | 29.2 | 36.9 | 55.6 | |||
| Gender | 0.8283 | 0.7747 | 0.9926 | |||
| Male | 35.3 | 35.9 | 60.8 | |||
| Female | 40.0 | 39.1 | 60.6 | |||
| Tumor size, cm | 0.0301 | 0.0096 | 0.2192 | |||
| ≥3.0 | 13.0 | 21.1 | 44.0 | |||
| <3.0 | 46.2 | 48.1 | 72.4 | |||
| T factor | 0.1274 | 0.0292 | 0.4011 | |||
| T1a-b | 43.5 | 47.4 | 69.6 | |||
| T2–4 | 20.2 | 24.8 | 50.4 | |||
| Histology | 0.6591 | 0.0501 | 0.4304 | |||
| Adenocarcinoma | 36.0 | 44.1 | 67.0 | |||
| Other | 28.5 | 22.4 | 47.9 | |||
| N factor | 0.3311 | 0.0604 | 0.1412 | |||
| Negative | 38.4 | 42.3 | 69.9 | |||
| Positive | 21.8 | 19.1 | 30.3 | |||
| p-Stage | 0.8674 | 0.4532 | 0.3573 | |||
| I–II | 34.6 | 38.8 | 65.4 | |||
| III | 31.3 | 28.1 | 37.1 | |||
| Ly factor | 0.5473 | 0.8568 | 0.6802 | |||
| Negative | 37.2 | 36.3 | 57.6 | |||
| Positive | 27.5 | 38.4 | 67.8 | |||
| V factor | 0.0630 | 0.1287 | 0.8245 | |||
| Negative | 41.9 | 50.0 | 62.3 | |||
| Positive | 9.7 | 24.2 | 57.0 | |||
| Pl factor | 0.0156 | 0.0849 | 0.6691 | |||
| Negative | 43.6 | 42.3 | 63.7 | |||
| Positive | 1.0 | 22.0 | 52.6 | |||
| Recurrence | 0.2634 | 0.1563 | 0.1760 | |||
| Yes | 17.4 | 22.8 | 31.3 | |||
| No | 38.3 | 40.9 | 68.7 | |||
FoxP3, forkhead box P3; n, factor, nodal invasion; ly factor, lymphatic invasion; v factor, venous invasion; pl factor, pleural invasion; c, central; i, interstitial.