Table 2.
Clinical pregnancy and live birth rates per couple, by randomization assignment for the first two treatment cycles and at the end of all treatment. Includes treatment-independent pregnancies.
| 1st two treatment cycles | Duration of study | ||||
|---|---|---|---|---|---|
| Randomized treatment arm | No. couples (%) | No. clinical pregnanciesa, b (%, 97.5% CI) | No. live birthsc (%, 97.5% CI) | No. clinical pregnanciesd (%, 97.5% CI) | No. live birthsd (%, 97.5% CI) |
| Clomiphene citrate (CC)/IUI | 51 (33.1) | 11 (21.6, 10.2–37.3) | 8 (15.7, 6.2–30.5) | 38 (74.5, 58.4–86.9) | 25 (49.0, 32.9–65.2) |
| Gonadotropin (FSH)/IUI) | 52 (33.8) | 9 (17.3, 7.3–32.2) | 7 (13.5, 4.9–27.6) | 34 (65.4, 49.0–79.5) | 22 (42.3, 27.1–58.7) |
| Immediate IVF | 51 (33.1) | 25 (49.0, 32.9–65.2) | 16 (31.4, 17.7–47.9) | 38 (74.5, 58.4–86.9) | 24 (47.1, 31.2–63.4) |
| Totale | 154 | 45 (29.2, 21.3–38.2) | 31 (20.1, 13.4–28.4) | 110 (71.4, 62.5–79.3) | 71 (46.1, 37.0–55.4) |
Abbreviations: IUI = Intrauterine insemination; IVF = In vitro fertilization.
Number of clinical pregnancies includes all ultrasound confirmed pregnancies, including pregnancy losses.
For clinical pregnancy rate after first two treatment cycles: P = 0.0067 for comparison between CC/IUI and immediate IVF; P = 0.0007 for comparison between FSH/IUI and immediate IVF.
For live birth rate after first two treatment cycles: P = 0.101 for comparison between CC/IUI and immediate IVF; P = 0.035 for comparison between FSH/IUI and immediate IVF.
For clinical pregnancy and live birth rates after all treatment there are no statistically significant differences, reflecting subsequent IVF treatment in all arms.
Of these, there were 5, 2, and 4 clinical pregnancies and 5, 1, and 3 live births in the CC/IUI, FSH/IUI and immediate IVF arms, respectively, that occurred before treatment was initiated or between treatment cycles one and two. Over the duration of the study there were 11, 3, and 9 clinical pregnancies and 7, 1, and 6 live births in the CC/IUI, FSH/IUI, and immediate IVF arms, respectively, that occurred outside of treatment cycles.