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. Author manuscript; available in PMC: 2014 Jul 22.
Published in final edited form as: Immunol Res. 2014 May;58(0):186–192. doi: 10.1007/s12026-014-8495-2

Fig. 1.

Fig. 1

Pro-inflammatory actions of LMW-HA and TLR signaling. LMW-HA characterizes inflamed tissues with active matrix catabolism. LMW-HA is an agonist of TLR signaling through interactions with TLR2 and/or TLR4 and communicates “danger signals” to infiltrating leukocytes. LMW-HA promotes leukocyte homing, proliferation and production of pro-inflammatory cytokine production as well as DC maturation and antigen presentation. LMW-HA also induces turnover of CD44, potentially limiting the likelihood of CD44 cross-linking by intact ECM