Table I.
No. | Gender | Age (yrs) | Type | Stage | Primary or recurrence | Group | Combined with | Cycles | CAa | PFS (mo) | OS (mo) |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | M | 45 | NK/T | I | Primary | TLD | CHOPb+RTc | 6 | CR | >42 | >42 |
2 | M | 42 | NK/T | I | Primary | TLD | CHOPb+RTc | 6 | CR | >33 | >33 |
3 | F | 40 | ALCL | I | Primary | TLD | CHOPb | 6 | CR | >32 | >32 |
4 | F | 51 | NK/T | II | Recurrence | TLD | DICEd | 4 | PD | 3 | 5 |
5 | M | 77 | AITL | II | Primary | TLD | COPe | 4 | PR | 3 | 7 |
6 | M | 33 | PTCL | III | Recurrence | TLD | CHOPb+RTc | 4 | PR | 2 | >5 |
7 | M | 70 | AITL | III | Primary | TLD | CHOPb | 4 | PR | 5 | >12 |
8 | M | 41 | NK/T | I | Primary | TLD | CHOPb+Gem+RTc | 6 | CR | >26 | >26 |
9 | M | 45 | PTCL | II | Recurrence | TLD | CHOPb | 3 | CR | >15 | >15 |
10 | M | 53 | T-LBL | IV | Recurrence | TLD | FMDf | 2 | PR | 7.5 | 11.5 |
11 | M | 75 | AITL | IV | Primary | TLD | CHOPb | 2 | SD | 4 | 7 |
12 | M | 39 | PTCL | IV | Primary | TLD | CHOPb+DDP+RTc | 7 | PR | 9 | 21 |
13 | F | 32 | SPTCL | I | Primary | TLD | CHOPb+DDP+RTc | 6 | CR | >21 | >21 |
14 | M | 71 | NK/T | IV | Recurrence | TLD | CHOPb+GEM | 5 | CR | 19 | >21 |
15 | F | 50 | AITL | IV | Primary | TLD | CHOPb+GEM | 5 | CR | >18 | >18 |
16 | M | 48 | NK/T | IV | Recurrence | TLD | GEM+L-OHP | 7 | CR | >16 | >16 |
17 | F | 73 | C-ALCL | IIIE | Recurrence | TLD | CHOPb | 2 | PD | 1 | >8 |
18 | F | 54 | ALCL | III | Recurrence | TLD | DICEd | 4 | PR | 12 | >14 |
19 | F | 58 | NK/T | III | Primary | TLD | CHOPb+RTc | 2 | CR | >13 | >13 |
20 | F | 74 | NK/T | IV | Primary | TLD | GEM+L-OHP | 2 | PD | 2 | 3 |
21 | F | 60 | NK/T | I | Primary | TLD | GEM+L-OHP+RTc | 4 | CR | >12 | >12 |
22 | M | 45 | NK/T | I | Primary | TLD | GEM+L-OHP | 2 | PD | 1 | 3 |
23 | M | 56 | NK/T | II | Primary | TLD | CHOPb+RTc | 2 | PR | 3 | 3 |
24 | F | 60 | NK/T | I | Primary | TLD | GEM+L-OHP+RTc | 3 | CR | >8 | >8 |
25 | M | 23 | PTCL | IV | Primary | Control | CHOPb | 2 | PD | 2 | 4 |
26 | M | 47 | NK/T | I | Primary | Control | CHOPb+RTc | 6 | CR | >37 | >37 |
27 | M | 60 | PTCL | III | Primary | Control | CHOPb | 6 | CR | >36 | >36 |
28 | F | 40 | PTCL | IV | Primary | Control | CHOPb+GEM | 5 | PR | 6 | 10 |
29 | M | 72 | ALCL | IV | Primary | Control | CHOPb+RTc | 6 | SD | 6 | 8 |
30 | M | 58 | PTCL | III | Primary | Control | CHOPb | 2 | PR | >3 | >3 |
31 | F | 35 | NK/T | II | Primary | Control | CHOPb | 2 | PD | 0 | 3 |
32 | M | 37 | NK/T | I | Primary | Control | CHOPb+RTc | 4 | CR | >34 | >34 |
33 | M | 29 | ALCL | III | Recurrence | Control | CHOPb+RTc | 6 | SD | 6 | >11 |
34 | M | 65 | ATCL | IV | Recurrence | Control | GEM+L-OHP | 3 | SD | 5 | 7 |
35 | M | 65 | NK/T | II | Primary | Control | CHOPb | 2 | PR | 5 | 6 |
36 | M | 58 | NK/T | I | Primary | Control | CHOPb+RTc | 2 | PR | 2 | 8 |
37 | M | 38 | NK/T | I | Primary | Control | GPh+DXM | 2 | PD | 2 | 4 |
38 | F | 62 | PTCL | I | Primary | Control | CHOPb+RTc | 6 | CR | >26 | >26 |
39 | M | 61 | NK/T | I | Primary | Control | CHOPb+RTc | 6 | CR | >23 | >23 |
40 | M | 40 | NK/T | II | Primary | Control | CHOPb | 6 | CR | >21 | >21 |
41 | M | 69 | PTCL | IV | Primary | Control | CHOPb | 8 | CR | 11 | 17 |
42 | M | 65 | ALCL | III | primary | Control | CHOPb | 2 | PD | 1 | 3 |
43 | M | 18 | ALCL | IV | Primary | Control | CHOPb | 2 | PR | 1 | >6 |
44 | M | 65 | ALCL | III | Primary | Control | CHOPb | 2 | PD | 1 | 3 |
45 | F | 68 | T-LBL | I | Primary | Control | CHOPb | 4 | PR | 15 | >15 |
46 | M | 36 | NK/T | II | Primary | Control | EPg | 5 | CR | >7 | >7 |
Clinical assessment.
Cyclophosphamide, adriamycin, vincristine and prednisone.
Local radiotherapy.
Dexamethasone, ifosfamide, cisplatin and etoposide.
Cyclophosphamide, vincristine and prednisone.
Fludarabine, mitoxantrone and dexamethasone.
Etoposide and cisplatin.
Gemcitabine and cisplatin.
T-NHL, T-cell non-Hodgkin’s lymphoma; PFS, progression-free survival; OS, overall survival; M, male; F, female; NK/T, natural killer/T-cell lymphoma; ALCL, anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma; AITL, angioimmunoblastic T-cell lymphoma; PTCL, peripheral T-cell lymphoma; T-LBL, precursor T-lymphoblastic lymphoma; SPTCL, subcutaneous panniculitis-like T-cell lymphoma; C-ALCL, primary cutaneous anaplastic large-cell lymphoma; ATCL, adult T-cell leukemia/lymphoma; TLD, thalidomide; GEM, gemcitabine; L-OHP, oxaliplatin; DXM, dextromethorphan; CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.