. 2014 Jun 6;2(5):737–743. doi: 10.3892/mco.2014.308

Table IV.

Characteristics of 9 patients with severe non-hematological toxicities.

Patient characteristics						Grade of adverse events^a

Age (years)	Gender	UGT1A1	PS	Pathology	cStage	FN	Diarrhea	Other severe NH toxicities^b

73	Female	Non-test	1	SCC	IV	4	-	-
83	Male	Non-test	1	NSCLC	IIIB	5	5	-
56	Male	Wild-type	1	Adenocarcinoma	IV	-	-	5^c
69	Male	Wild-type	1	SCC	IV	-	-	5^c
72	Male	Wild-type	1	Adenocarcinoma	IV	5	5	-
73	Male	Wild-type	1	SCC	IV	4	3	-
77	Male	^*28 heterozygous	0	Adenocarcinoma	IV	4	4	-
67	Male	^*6 heterozygous	1	LCNEC	IV	-	-	4^d
78	Male	^*6 heterozygous	1	SCLC	IV	4	3	-

Adverse events ≥grade 3.

Other grade 4 and 5 adverse events.

Interstitial pneumonitis.

Bowel perforation.

LCNEC, large-cell neuroendocrine carcinoma; FN, febrile neutropenia; NH, non-hematological; UGT1A1, UDP glucuronosyltransferase 1 family, polypeptide A1; PS, performance status; SCC, squamous cell carcinoma; SCLC, small-cell lung cancer; NSCLC, non-small-cell lung cancer.